TPCA-1
TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.
| Trivial name | GW683965 |
| Catalog Number | S2824 |
| Molecular Formula | C26H31ClN6O2 |
| CAS# | 507475-17-4 |
| Inchi | InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s 1 |
| Inchi Key | IOMMMLWIABWRKL-WUTDNEBXSA-N |
| SMILES | CC1=NC=CC(=C1)C(=O)NC2=NC3=C(N2C4CCCCN(C4)C(=O)C=CCN(C)C)C(=CC=C3)Cl |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/tpca-1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TPCA-1-chemical-structure-s2824.gif |