NU7441 (KU-57788)
NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
| Trivial name | N/A |
| Catalog Number | S2638 |
| Molecular Formula | C25H19NO3S |
| CAS# | 503468-95-9 |
| Inchi | InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2 |
| Inchi Key | JAMULYFATHSZJM-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/nu7441.html |
| Additional Information | https://file.selleck.cn/downloads/struct/NU7441-chemical-structure-s2638.gif |