GANT61
GANT61 (NSC 136476) is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM in GLI1 expressing HEK293T cell, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. GANT61 induces apoptosis and activates protective autophagy in LX-2 cells.
| Trivial name | NSC 136476 |
| Catalog Number | S8075 |
| Molecular Formula | C27H35N5 |
| CAS# | 500579-04-4 |
| Inchi | InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3 |
| Inchi Key | KVQOGDQTWWCZFX-UHFFFAOYSA-N |
| SMILES | CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/gant61.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GANT-61-chemical-structure-s8075.gif |