Niclosamide
Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
| Trivial name | BAY2353, Niclocide, NSC 178296 |
| Catalog Number | S3030 |
| Molecular Formula | C21H18Br2N2O |
| CAS# | 50-65-7 |
| Inchi | InChI=1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2 |
| Inchi Key | FZHHRERIIVOATI-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/niclosamide-niclocide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Niclosamide-chemical-structure-s3030.gif |