Givinostat
Givinostat is an orally active, hydroxamic acid-containing inhibitor of histone deacetylases (HDACs), with the potential to treat children with systemic juvenile idiopathic arthritis. It primarily targets Class I and II HDACs, with IC50 of 198 nM and 157 nM for HDAC1 and HDAC3, respectively.
| Trivial name | ITF-2357 |
| Catalog Number | E7481 |
| Molecular Formula | C21H32O2 |
| CAS# | 497833-27-9 |
| Inchi | InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 |
| Inchi Key | ORNBQBCIOKFOEO-QGVNFLHTSA-N |
| SMILES | CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/givinostat.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7481-Givinostat-chemical-structure.png |