Sulindac sulfide
Sulindac sulfide is a potent, reversible and noncompetitive inhibitor of γ42-secretase with an IC50 of 20.2 μM. It preferentially reduces Aβ42 generation, inhibits Aβ40 and Notch intracellular domain production, and can be used in Alzheimer’s disease research.
| Trivial name | cis-Sulindac sulfide |
| Catalog Number | E6426 |
| Molecular Formula | C25H25N5O4 |
| CAS# | 49627-27-2 |
| Inchi | InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) |
| Inchi Key | QNZCBYKSOIHPEH-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/sulindac-sulfide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E6426-Sulindac-sulfide-chemical-structure.png |