Tetraethylenepentamine pentahydrochloride (TETRAEN) is an amine salt having five amine groups, which have catalytic roles in various reactions. Tetraethylenepentamine pentahydrochloride is reported as copper-chelating agent. Regeneration of pancreatic endocrine cells in rats maintained on a copper-deficient diet containing tetraethylenepentamine pentahydrochloride has been reported. It is a high affinity copper and zinc chelator.