Vasicinone| ChemScene
Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson’s disease and possibly other oxidative stress-related neurodegenerative disorders.In Vitro: Vasicinone (1~30 μM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability.
Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death.
Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins.
Trivial name | Vasicinone |
Catalog Number | CS-0016388 |
Alternative Name(s) | (-)-Vasicinone |
Molecular Formula | 202.21 |
CAS# | 486-64-6 |
Purity | >98% |
Condensed Formula | C11H10N2O2 |
Size | 1mg |
Supplier Page | www.chemscene.com/486-64-6.html |