Purmorphamine
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.
| Trivial name | Shh Signaling Antagonist VI |
| Catalog Number | S3042 |
| Molecular Formula | C31H32N6O2 |
| CAS# | 483367-10-8 |
| Inchi | InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35) |
| Inchi Key | FYBHCRQFSFYWPY-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/purmorphamine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/purmorphamine-chemical-structure-s3042.jpg |