Tofacitinib
Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.
| Trivial name | CP-690550, Tasocitinib |
| Catalog Number | S2789 |
| Molecular Formula | C46H55N7O7S |
| CAS# | 477600-75-2 |
| Inchi | InChI=1S/C46H55N7O7S/c1-33-43(41(49(4)47-33)32-60-36-19-17-35(18-20-36)51-22-24-52(25-23-51)61(56,57)48(2)3)40-14-8-13-38-39(15-9-29-59-42-16-7-11-34-10-5-6-12-37(34)42)45(46(54)55)53(44(38)40)26-21-5 0-27-30-58-31-28-50/h5-8,10-14,16-20H,9,15,21-32H2,1-4H3,(H,54,55) |
| Inchi Key | XMVAWGSQPHFXKU-UHFFFAOYSA-N |
| SMILES | CC1=NN(C(=C1C2=CC=CC3=C2N(C(=C3CCCOC4=CC=CC5=CC=CC=C54)C(=O)O)CCN6CCOCC6)COC7=CC=C(C=C7)N8CCN(CC8)S(=O)(=O)N(C)C)C |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/tofacitinib-cp-690550.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CP-690550-chemical-structure-s2789.gif |