Sorafenib tosylate

Sorafenib tosylate is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

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Trivial name	BAY 43-9006 tosylate,NSC-724772 tosylate
Catalog Number	S1040
Molecular Formula	C21H16ClF3N4O3.C7H8O3S
CAS#	475207-59-1
Inchi	InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H ,8,9,10)
Inchi Key	IVDHYUQIDRJSTI-UHFFFAOYSA-N
SMILES	CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/Sorafenib-Tosylate.html
Additional Information	https://file.selleck.cn/downloads/struct/Sorafenib-Nexavar-chemical-structure-S1040.gif