Jervine
Jervine (11-Ketocyclopamine) is a Hedgehog signaling (IC50=500-700 nM) inhibitor that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened.
| Trivial name | 11-Ketocyclopamine |
| Catalog Number | S4747 |
| Molecular Formula | C27H39NO3 |
| CAS# | 469-59-0 |
| Inchi | InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-, 27-/m0/s1 |
| Inchi Key | CLEXYFLHGFJONT-DNMILWOZSA-N |
| SMILES | CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)O)C)NC1 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/jervine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/jervine-chemical-structure-s4747.gif |