Pamapimod
Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.
| Trivial name | R-1503,Ro4402257 |
| Catalog Number | S8125 |
| Molecular Formula | C19H20F2N4O4 |
| CAS# | 449811-01-2 |
| Inchi | InChI=1S/C19H20F2N4O4/c1-25-17-11(10-22-19(24-17)23-13(4-6-26)5-7-27)8-16(18(25)28)29-15-3-2-12(20)9-14(15)21/h2-3,8-10,13,26-27H,4-7H2,1H3,(H,22,23,24) |
| Inchi Key | JYYLVUFNAHSSFE-UHFFFAOYSA-N |
| SMILES | CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC(CCO)CCO |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/pamapimod-r-1503-ro4402257.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pamapimod-r-1503-ro4402257-chemical-structure-s8125.gif |