Sulforaphane, a natural product isolated and purified from the seeds of Brassica oleracea L. var. botrytis L. with neuroprotective, anti-inflammatory and antitumor effects, inhibits TPA-induced NF-κB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKα and NAK-IKKβ.