Pazopanib
Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.
| Trivial name | GW786034 |
| Catalog Number | S3012 |
| Molecular Formula | C21H23N7O2S |
| CAS# | 444731-52-6 |
| Inchi | InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) |
| Inchi Key | CUIHSIWYWATEQL-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/pazopanib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Pazopanib-chemical-structure-s3012.gif |