JNJ-7706621
JNJ-7706621 is a pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.
| Trivial name | N/A |
| Catalog Number | S1249 |
| Molecular Formula | C15H12F2N6O3S |
| CAS# | 443797-96-4 |
| Inchi | InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) |
| Inchi Key | KDKUVYLMPJIGKA-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/JNJ-7706621.html |
| Additional Information | https://file.selleck.cn/downloads/struct/JNJ-7706621-chemical-structure-S1249.gif |