JNJ-7706621
JNJ-7706621 is a pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.
| Trivial name | N/A |
| Catalog Number | S1249 |
| Molecular Formula | C26H22FN7O3 |
| CAS# | 443797-96-4 |
| Inchi | InChI=1S/C26H22FN7O3/c1-14-22(25(36)32-17-6-8-21-16(10-17)12-30-34-21)23(33-26(37)31-14)15-5-7-20(27)19(11-15)24(35)29-13-18-4-2-3-9-28-18/h2-12,23H,13H2,1H3,(H,29,35)(H,30,34)(H,32,36)(H2,31,33,37) |
| Inchi Key | BLMBNKDQXGINRE-UHFFFAOYSA-N |
| SMILES | CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC3=CC=CC=N3)C(=O)NC4=CC5=C(C=C4)NN=C5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/JNJ-7706621.html |
| Additional Information | https://file.selleck.cn/downloads/struct/JNJ-7706621-chemical-structure-S1249.gif |