Harmine
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.
| Trivial name | Telepathine |
| Catalog Number | S3868 |
| Molecular Formula | C24H27N3O2 |
| CAS# | 442-51-3 |
| Inchi | InChI=1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3 |
| Inchi Key | OKTGXQMSOIQCTJ-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)CCC(=O)N(C2CCCNC2)C3=NC=CC4=CC=CC=C43 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/harmine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/harmine-chemical-structure-s3868.gif |