Afatinib free base
Afatinib free base (Gilotrif, BIBW2992, Boehringer Ingelheim) is a second-generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 14 nM and 1 nM for wild-type EGFR, EGFR-L858R, HER2, ErbB4, respectively.
| Trivial name | Gilotrif, BIBW2992, Boehringer Ingelheim |
| Catalog Number | E4819 |
| Molecular Formula | C19H14Cl2N2O3S |
| CAS# | 439081-18-2 |
| Inchi | InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24) |
| Inchi Key | BPQMGSKTAYIVFO-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/afatinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4819-Afatinib-free-base-chemical-structure.png |