Afatinib
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
| Trivial name | BIBW2992 |
| Catalog Number | S1011 |
| Molecular Formula | C6H7NO3S |
| CAS# | 850140-72-6 |
| Inchi | InChI=1S/C6H7NO3S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H,8,9,10) |
| Inchi Key | ZMCHBSMFKQYNKA-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)N)S(=O)(=O)O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/BIBW2992.html |
| Additional Information | https://file.selleck.cn/downloads/struct/afatinib-bibw2992-chemical-structure-s1011.gif |