Afatinib
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
| Trivial name | BIBW2992 |
| Catalog Number | S1011 |
| Molecular Formula | C6H4O2 |
| CAS# | 850140-72-6 |
| Inchi | #N/A |
| Inchi Key | #N/A |
| SMILES | O=C1C=CC(=O)C=C1 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/BIBW2992.html |
| Additional Information | https://file.selleck.cn/downloads/struct/afatinib-bibw2992-chemical-structure-s1011.gif |