SKLB-11A
SKLB-11A is a selective, first-in-class allosteric activator of SIRT3 that binds with a Kd of 4.7 μM and enhances its deacetylase activity with EC50 of 21.95 μM. It improves cardiac function and alleviates myocardial damage in vivo.
| Catalog Number | E5988 |
| Molecular Formula | C14H8N2O |
| CAS# | 433953-86-7 |
| Inchi | InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
| Inchi Key | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/sklb-11a.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5988-SKLB-11A-chemical-structure.png |