Semagacestat (LY450139)
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.
| Trivial name | N/A |
| Catalog Number | S1594 |
| Molecular Formula | C26H42N6O12S2 |
| CAS# | 425386-60-3 |
| SMILES | CSCCC(NC=O)C(=O)NC(CC(O)=O)C(=O)NCC(=O)NC(CS)C(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(O)=O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Semagacestat(LY450139).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Semagacestat-LY450139-chemical-structure-S1594.gif |