Semagacestat (LY450139)

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.

Price Not Available 10mM/1mL Semagacestat (LY450139) Supplier Page

Trivial name	N/A
Catalog Number	S1594
Molecular Formula	C19H27N3O4
CAS#	425386-60-3
Inchi	InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1
Inchi Key	PKXWXXPNHIWQHW-RCBQFDQVSA-N
SMILES	CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2CCN(C1=O)C)O
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/Semagacestat(LY450139).html
Additional Information	https://file.selleck.cn/downloads/struct/Semagacestat-LY450139-chemical-structure-S1594.gif