Polyinosinic-polycytidylic acid sodium
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic double-stranded RNA (dsRNA) analogue that activates the MDA-5 receptor in the cytoplasm and TLR3 in endosomal compartments. This activation promotes the production of type I interferons and induces apoptosis in cancer cells, particularly those that lack protective anti-apoptotic mechanisms like Bcl-xL.
| Trivial name | Poly(I:C) sodium |
| Catalog Number | E4998 |
| Molecular Formula | C19H26O3 |
| CAS# | 42424-50-0 |
| Inchi | InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1 |
| Inchi Key | CQOQDQWUFQDJMK-SSTWWWIQSA-N |
| SMILES | CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)OC)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/polyinosinic-polycytidylic-acid-sodium.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4998-Polyinosinic-polycytidylic-acid-sodium-chemical-structure.png |