Lenvatinib
Lenvatinib is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities. Phase 3.
| Trivial name | E7080 |
| Catalog Number | S1164 |
| Molecular Formula | C26H41Br2NO4 |
| CAS# | 417716-92-8 |
| Inchi | InChI=1S/C26H41BrNO4.BrH/c1-26(2)21-6-5-19(22(26)16-21)7-11-31-12-8-28(9-13-32-14-10-28)18-20-15-24(29-3)25(30-4)17-23(20)27;/h15,17,19,21-22H,5-14,16,18H2,1-4H3;1H/q+1;/p-1 |
| Inchi Key | IKGXLCMLVINENI-UHFFFAOYSA-M |
| SMILES | CC1(C2CCC(C1C2)CCOCC[N+]3(CCOCC3)CC4=CC(=C(C=C4Br)OC)OC)C.[Br-] |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/E7080.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7080-chemical-structure-S1164.gif |