Dovitinib (TKI-258)
Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.
| Trivial name | CHIR-258 |
| Catalog Number | S1018 |
| Molecular Formula | C21H21FN6O |
| CAS# | 405169-16-6 |
| Inchi | InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) |
| Inchi Key | PIQCTGMSNWUMAF-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/CHIR-258.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Dovitinib-chemical-structure-s1018.gif |