CHIR-124
CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.
| Trivial name | N/A |
| Catalog Number | S2683 |
| Molecular Formula | C23H22ClN5O |
| CAS# | 405168-58-3 |
| Inchi | InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(H2,25,28,30)/t19-/m1/s1 |
| Inchi Key | MOVBBVMDHIRCTG-LJQANCHMSA-N |
| SMILES | C1CN2CCC1C(C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/chir-124.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CHIR124-chemical-structure-s2683.gif |