Panobinostat (LBH589)
Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8 nM.
| Catalog Number | ABH-016 |
| Alternative Name(s) | LBH589, LBN-589,NVP-LBH589 |
| CAS# | 404950-80-7 |
| Inchi | InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+ |
| Inchi Key | FPOHNWQLNRZRFC-ZHACJKMWSA-N |
| SMILES | CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/panobinostat-lbh589-item-1431.html |