Mirdametinib (PD0325901)
Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.
Trivial name | N/A |
Catalog Number | S1036 |
Molecular Formula | C16H14F3IN2O4 |
CAS# | 391210-10-9 |
Inchi | InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 |
Inchi Key | SUDAHWBOROXANE-SECBINFHSA-N |
SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/PD-0325901.html |
Additional Information | https://file.selleck.cn/downloads/struct/PD0325901-chemical-structure-S1036.gif |