Triptolide

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.

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Trivial name	PG490, NSC 163062
Catalog Number	S3604
Molecular Formula	C20H24O6
CAS#	38748-32-2
Inchi	InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
Inchi Key	DFBIRQPKNDILPW-CIVMWXNOSA-N
Size	100mg
Supplier Page	http://www.selleckchem.com/products/triptolide.html
Additional Information	https://file.selleck.cn/downloads/struct/Triptolide-chemical-structure-s3604.jpg