Bosutinib
Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
| Trivial name | SKI-606 |
| Catalog Number | S1014 |
| Molecular Formula | C26H29Cl2N5O3 |
| CAS# | 380843-75-4 |
| Inchi | InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) |
| Inchi Key | UBPYILGKFZZVDX-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/Bosutinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Bosutinib-SKI-606-chemical-structure-S1014.gif |