Bosutinib
Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
| Trivial name | SKI-606 |
| Catalog Number | S1014 |
| Molecular Formula | C10H8N2 |
| CAS# | 380843-75-4 |
| Inchi | InChI=1S/C10H8N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5H2 |
| Inchi Key | DMCPFOBLJMLSNX-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=CN2)CC#N |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/Bosutinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Bosutinib-SKI-606-chemical-structure-S1014.gif |