MPP+ iodide
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson’s disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.
| Trivial name | N-Methyl-4-Phenylpyridinium Iodide |
| Catalog Number | S6301 |
| Molecular Formula | C12H12IN |
| CAS# | 36913-39-0 |
| Inchi | #N/A |
| Inchi Key | #N/A |
| SMILES | [I-].C[N+]1=CC=C(C=C1)C2=CC=CC=C2 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/mpp-iodide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s6301-mpp-iodide-chemical-structure.gif |