Cryptotanshinone (Tanshinone C)
Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.
Catalog Number | S2285 |
Molecular Formula | C26 H29 Cl N2 O4 S . H3 O4 P |
CAS# | 35825-57-1 |
Inchi | InChI=1S/C26H29ClN2O4S.H3O4P/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25;1-5(2,3)4/h3-16,30H,17-20H2,1-2H3;(H3,1,2,3,4)/b6-5+; |
Inchi Key | NNKJTPOXLIILMB-IPZCTEOASA-N |
SMILES | CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O |
Size | 50mg |
Supplier Page | http://www.selleckchem.com/products/Cryptotanshinone.html |
Additional Information | https://file.selleck.cn/downloads/struct/Cryptotanshinone-chemical-structure-S2285.gif |