Harmine hydrochloride
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.
| Trivial name | Telepathine hydrochloride |
| Catalog Number | S3817 |
| Molecular Formula | C18H17ClN4O |
| CAS# | 343-27-1 |
| Inchi | InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1 |
| Inchi Key | ODRITQGYYWHQGM-INIZCTEOSA-N |
| SMILES | CC1=C2C=C(C=NC2=NN1)C(=O)N3CCCC3C4=CC=C(C=C4)Cl |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/harmine-hydrochloride.html |
| Additional Information | https://file.selleck.cn/downloads/struct/harmine-hydrochloride-chemical-structure-s3817.gif |
