Celastrol
Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson’s disease through activating mitophagy.
Trivial name | NSC 70931, Tripterine |
Catalog Number | S1290 |
Molecular Formula | C17H17N3O |
CAS# | 34157-83-0 |
Inchi | InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21) |
Inchi Key | UJZDIKVQFMCLBE-UHFFFAOYSA-N |
SMILES | CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32 |
Size | 50mg |
Supplier Page | http://www.selleckchem.com/products/Celastrol.html |
Additional Information | https://file.selleck.cn/downloads/struct/Celastrol-chemical-structure-S1290.gif |