Sunitinib malate
Sunitinib malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.
| Trivial name | SU11248 malate |
| Catalog Number | S1042 |
| Molecular Formula | C15H26O |
| CAS# | 341031-54-7 |
| Inchi | InChI=1S/C15H26O/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14/h6-7,14,16H,5,8-11H2,1-4H3/t14-,15+/m0/s1 |
| Inchi Key | RGZSQWQPBWRIAQ-LSDHHAIUSA-N |
| SMILES | CC1=CCC(CC1)C(C)(CCC=C(C)C)O |
| Size | 500mg |
| Supplier Page | http://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Sunitinib-Sutent-chemical-structure-S1042.gif |
