1,4-DPCA
1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM.
| Catalog Number | E7385 |
| Molecular Formula | C21H20O6 |
| CAS# | 331830-20-7 |
| Inchi | InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13- |
| Inchi Key | ZIUSSTSXXLLKKK-KOBPDPAPSA-N |
| SMILES | COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/1-4-dpca.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7385-1-4-dpca-chemical-structure-tube.png |