KIN-8194 | MedChemExpress (MCE)
KIN-8194 is an orally active dual inhibitor of HCK and BTK, with IC50 values of 0.915 and <0.495 nM, respectively. KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma (MCL). KIN-8194 overcomes ibrutinib (HY-10997) resistance with a survival benefit in TMD-8 ABC DLBCL xenografted mice[1][2].
| Trivial name | KIN-8194 |
| Catalog Number | HY-15805 |
| Research Area | Cancer |
| CAS# | 330786-01-1 |
| Purity | ≥98.0% |
| SMILES | NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN2[C@H]5CC[C@H](N6CCN(C)CC6)CC5 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/kin-8194.html |