LXG6403
LXG6403 is a bi-thiazole potent inhibitor of LOX cellular activity with an IC50 of 1.3 μM. It exhibits anti-cancer activity by remodeling the extracellular matrix, enhancing chemotherapy penetration, inducing ROS generation, and promoting DNA damage-mediated cell death to overcome chemotherapy resistance in triple-negative breast cancer.
| Catalog Number | E5913 |
| Molecular Formula | C20H27NO3 |
| CAS# | 315705-04-5 |
| Inchi | InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1 |
| Inchi Key | KVJXBPDAXMEYOA-CXANFOAXSA-N |
| SMILES | CC12CCC3C(C1CCC2O)CCC45C3(CC(=C(C4O5)O)C#N)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/lxg6403.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5913-LXG6403-chemical-structure.png |