ICA-121431
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).
| Catalog Number | E7595 |
| Molecular Formula | C12H13ClN4 |
| CAS# | 313254-51-2 |
| Inchi | InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17) |
| Inchi Key | WKSAUQYGYAYLPV-UHFFFAOYSA-N |
| SMILES | CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ica-121431.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7595-ica-121431-chemical-structure-tube.png |