Talmapimod
Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.
| Trivial name | SCIO-469 |
| Catalog Number | E7025 |
| Molecular Formula | C4H13NO7P2.3H2O.Na |
| CAS# | 309913-83-5 |
| Inchi | InChI=1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1 |
| Inchi Key | DCSBSVSZJRSITC-UHFFFAOYSA-M |
| SMILES | C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+] |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/talmapimod.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7025-talmapimod-chemical-structure-tube.png |