Geldanamycin
Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host’s inflammatory responses.
| Trivial name | NSC 122750 |
| Catalog Number | S2713 |
| Molecular Formula | C29H40N2O9 |
| CAS# | 30562-34-6 |
| Inchi | InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/ b10-8+,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1 |
| Inchi Key | QTQAWLPCGQOSGP-PHLMVCJGSA-N |
| SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/geldanamycin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Geldanamycin-chemical-structure-s2713.gif |