LYG-409
LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.
| Catalog Number | E5877 |
| Molecular Formula | C15H18N4O4S |
| CAS# | 3053857-55-6 |
| Inchi | InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/t7-,8-,10-,11-/m1/s1 |
| Inchi Key | MRMBZHPJVKCOMA-YJFSRANCSA-N |
| SMILES | CC1C2C(C(=O)N2C(=C1SC3CN4C=NC=[N+]4C3)C(=O)[O-])C(C)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/lyg-409.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5877-LYG-409-chemical-structure.png |