YJ1206
YJ1206 is an orally bioavailable, highly specific and potent degrader of CDK12/13 with an IC50 of 12.55 nM in VCaP cells. It increases DNA damage, induces apoptosis, and demonstrates robust anti-tumor activity in vivo.
| Catalog Number | E4760 |
| Molecular Formula | C17H22N2O3 |
| CAS# | 3053716-98-3 |
| Inchi | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
| Inchi Key | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| SMILES | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/yj1206.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4760-YJ1206-chemical-structure.png |