YJ1206
YJ1206 is an orally bioavailable, highly specific and potent degrader of CDK12/13 with an IC50 of 12.55 nM in VCaP cells. It increases DNA damage, induces apoptosis, and demonstrates robust anti-tumor activity in vivo.
| Catalog Number | E4760 |
| Molecular Formula | C22H24BrFN4O2 |
| CAS# | 3053716-98-3 |
| Inchi | InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) |
| Inchi Key | UHTHHESEBZOYNR-UHFFFAOYSA-N |
| SMILES | CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/yj1206.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4760-YJ1206-chemical-structure.png |