VAV1 degrader-3
VAV1 degrader-3 (MRT-6160) is an orally active molecular glue degrader of VAV1 with a DC50 of 7 nM. It suppresses immune activation, proliferation, and cytokine production, inhibiting disease progression in inflammatory and autoimmune models like encephalomyelitis (EAE) and Collagen-induced arthritis (CIA).
| Trivial name | MRT-6160 |
| Catalog Number | E5871 |
| Molecular Formula | C21H24NNaO8S |
| CAS# | 3050683-38-7 |
| Inchi | InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+; |
| Inchi Key | VLQLUZFVFXYXQE-USRGLUTNSA-M |
| SMILES | COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+] |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/vav1-degrader-3.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5871-VAV1-degrader-3-chemical-structure.png |