SDU-071
SDU-071 is an inhibitor of BRD4-p53 protein-protein interaction with IC50 of 2.7 μM, which suppresses MDA-MB-231 triple-negative breast cancer (TNBC) cell migration, invasion, and in vivo tumor growth. It also exhibits antiproliferative activity in concentration concentration-dependent manner, with IC50 of 10.5 μM (72 h) and 12.6 μM (96 h) in MDA-MB-231 cells.
| Catalog Number | E4712 |
| Molecular Formula | C26H29Cl2N5O3 |
| CAS# | 3036109-10-8 |
| Inchi | InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) |
| Inchi Key | UBPYILGKFZZVDX-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/sdu-071.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4712-SDU-071-chemical-structure.png |