VVD-130037(BAY-3605349)
VVD-130037(BAY-3605349) is an orally available covalent small molecule activator of Kelch-like ECH associated protein 1 (KEAP1), which provide enhanced cellular degradation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) resulting in significant inhibition of tumor growth in advanced solid tumors.
Trivial name | BAY-3605349 |
Catalog Number | E4728 |
Molecular Formula | C13H13N3O3 |
CAS# | 3034880-93-5 |
Inchi | InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) |
Inchi Key | GOTYRUGSSMKFNF-UHFFFAOYSA-N |
SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N |
Size | 1g |
Supplier Page | http://www.selleckchem.com/products/vvd-130037.html |
Additional Information | https://file.selleck.cn/downloads/struct/E4728-VVD-130037-BAY-3605349-chemical-structure.png |