SIK-IN-2 | MedChemExpress (MCE)
SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages[1].
| Trivial name | SIK-IN-2 |
| Catalog Number | HY-161441 |
| Research Area | Inflammation/Immunology |
| CAS# | 3033846-20-4 |
| Purity | ≥98.0% |
| SMILES | N#CC1=C(N)C=CC2=NC=C(C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3)N21 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/sik-in-2.html |