PB94
PB94 is a potent and selective inhibitor of HDAC11 with an IC50 of 108 nM and exhibits >40-fold selectivity over other HDAC isoforms. It ameliorates neuropathic pain in mouse models and can be radiolabeled with carbon-11 as [¹¹C]PB94 for PET imaging, demonstrating significant brain uptake and potential for in vivo imaging applications.
| Catalog Number | E5948 |
| Molecular Formula | C20H28N2O5S·HCl |
| CAS# | 3032970-74-1 |
| Inchi | InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 |
| Inchi Key | DRHKJLXJIQTDTD-OAHLLOKOSA-N |
| SMILES | CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/pb94.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5948-PB94-chemical-structure.png |