OICR-8268
OICR-8268 is a potent, reversible and in-cell active DCAF1 ligand. It significantly binds to DCAF1 WDR domain with an Kd value of 38 nM. It serves as a promising starting point for developing chemical handles for DCAF1-based PROTACs targeting selective protein degradation as well as cancer therapeutics.
| Catalog Number | E5839 |
| Molecular Formula | C17H18F3NO.HCl |
| CAS# | 3000549-26-5 |
| Inchi | InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H |
| Inchi Key | GIYXAJPCNFJEHY-UHFFFAOYSA-N |
| SMILES | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/oicr-8268.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5839-OICR-8268-chemical-structure.png |